As the most abundant protein in the human body, collagen has many roles. It is often referred to as the scaffolding in the skin, providing strength and elasticity, while also credited with muscle and tendon health. The problem? Our natural collagen production declines from our mid-20s. Which is where supplementation comes in.
Vogue’s Favorite Anti-Aging Products
A divisive topic among experts on their effectiveness, collagen supplements were recently the subject of the most extensive study to date. This revealed that “In relation to skin, musculoskeletal health, and osteoarthritis conditions, collagen supplementation was consistently associated with favorable outcomes,” detailed the report entitled Collagen Supplementation for Skin and Musculoskeletal Health and published in the Aesthetic Surgery Journal Open Forum in January 2026.
Hyaluronic acid has similarly been the subject of many clinical studies as a topical skin-care ingredient, oral supplement and as injectables. Found naturally in the skin, it is a hydration powerhouse. As a humectant, it acts much like a sponge, drawing in moisture and holding up to 1,000 times its weight. This is why it is a renowned plumping agent, improving skin texture, tone and the appearance of wrinkles.
Collagen and hyaluronic acid have become the two headline ingredients in modern beauty marketing as both have a part to play in enhancing skin’s resilience, but which is more important? The answer is simple: they both are in their own ways. “They do different jobs, so it’s not really a competition,” explains dermatological doctor, Dr. Nora Jaafar. “Importantly, they address two concerns consumers notice quickly: wrinkles and dryness. If collagen loss is one of the key biological drivers of aging, hyaluronic acid loss is one of the key visual contributors. One affects structure, the other hydration.”
Below, Dr. Jaafar and Dr. Fiona McCarthy, the medical director and founder of The Bronte Clinic and a consultant medical oncologist, breakdown the two ingredients, detailing what they do, who should use them and how you can most effectively incorporate them into your skin-care routine.
Collagen vs Hyaluronic Acid: What does each ingredient do?
Putting it simply, “Collagen is associated with firmness and youthfulness,” Dr. Jaafar tells me. “It provides the skin’s structural framework, helping maintain firmness, elasticity, and support.” As mentioned above, the concern comes from the fact that collagen depletes by one percent per year from our mid-twenties, and Dr. McCarthy says that this accelerates even further during the perimenopause years due to estrogen deprivation. This results in “sagging, jowling, deepening lines and wrinkles, and loss of facial definition.”
